[S] competing risks and cumulative conditional probability of cause-s

Abdolell, Mohamed (Mohamed_Abdolell@pmh.toronto.on.ca)
Mon, 21 Sep 1998 12:54:44 -0400


The issue of competing risks is a real concern when considering
cause-specific failure, particularly in cancers such as breast and prostate.
Kaplan-Meier curves are not appropriate for summarizing failure time data
such as local recurrence since K-M curves over-estimate the probability of
cause-specific failure when there is a high mortality rate. Pepe and Mori
[Statistics in Medicine, Vol.12, 737-751 (1993)] propose the use of
cumulative incidence and cumulative conditional probability to accurately
give the probability and risk of cause-specific failure.

Has anyone seen or developed algorithms in Splus to address this issue?
Any help would be greatly appreciated.

Thanks in advance.

M. Abdolell
___________________________________________
Ontario Cancer Institute / Princess Margaret Hospital
Biostatistics Department
610 Universtiy Ave., Rm 15-422
Toronto, ON M5G 2M9
Tel. (416)946-2000 x4879

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end
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